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[The relationship between haplotypes of multilocus markers and ankylosing spondylitis]
Ming-min Gu1, Wen-tao Yuan, Jue-qin Yang
1Department of Medical Genetics,Shanghai Second Medical University, Shanghai, 200025 PR China.
Objective:
To investigate the relationship between haplotypes of multilocus markers and ankylosing spondylitis (AS).
Methods:
Five families with AS were recruited from Shanghai area. Eleven microsatellite markers around D6S276 were analyzed by Linkage package and by Cyrillic package.
Results:
Fine linkage analysis showed the significant Lod score values with D6S276 was 3.8821, Lod score values with D6S1691 and D6S1618 near D6S276 were larger than 1.5. The crossover value in 5 pedigrees was 14%. The haplotype analysis showed that the regions between D6S1691 and D6S1618 were associated with AS.
Conclusion:
The regions of D6S1691-D6S276-D6S1618 may harbor a susceptible gene of AS. The specific haplotypes of different pedigrees may play an important role in the presymptomatic diagnosis for AS.
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