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Updated: Aug 23, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility]
Xiao-ping Zhao1, Hui-min Zheng, Hui-jun Xie
1Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 PR China. xiaopingzhao1@263.net
Objective:
To explore the association of the microsatellite polymorphisms in the promoter region of alpha-synuclein gene with the late-onset sporadic Parkinson's disease (PD) susceptibility.
Methods:
The microsatellite polymorphism of alpha-synuclein gene was analyzed with amplified fragment length polymorphism (Amp-FLP) and semiautomatic fluorescent labeled genotyping technique. Association analysis was performed in 135 unrelated late-onset sporadic PD patients and 170 age-matched healthy controls.
Results:
The distribution of the alleles of the dinucleotide repeats variants of alpha-synuclein gene promoter region in PD cases was significantly different from that in the healthy controls. The most frequent allele in PD patients was allele 269 bp, but in controls it was the 271 bp allele. Alleles of
Conclusion:
alpha-synuclein microsatellite polymorphism might be a genetic susceptibility factor for late-onset sporadic PD.
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