Related Experiment Videos
Adrafinil-induced orofacial dyskinesia
Stéphane Thobois1, Jing Xie, Helena Mollion
1Department of Neurology, The Pierre Wertheimer Neurological Hospital, Lyon, France. stephane.thobois@chu-lyon.fr
Summary
Adrafinil, a vigilance-promoting drug, can cause orofacial abnormal movements. These movements improved with tetrabenazine treatment after failing to resolve after drug withdrawal.
Area of Science:
- Neuropharmacology
- Movement Disorders
Background:
- Adrafinil is a vigilance-promoting agent.
- It belongs to the same pharmacological class as modafinil.
Observation:
- A case of orofacial abnormal movements induced by adrafinil is reported.
- These movements persisted for 4 months after adrafinil withdrawal.
Findings:
- Dyskinesias were dramatically improved by tetrabenazine.
- Tetrabenazine is a presynaptic dopaminergic depleting drug.
Implications:
- This case highlights a potential adverse effect of adrafinil.
- Tetrabenazine may be an effective treatment for adrafinil-induced dyskinesias.