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Allergic eosinophilic gastroenteritis in a child with Crohn's disease

R Tella1, P Gaig, M Lombardero

  • 1Allergy Unit, Hospital Universitari Joan XXIII, Institut d'Estudis Avancats, Universitat Rovira i Virgili, Tarragona.

Journal of Investigational Allergology & Clinical Immunology
|August 11, 2004
PubMed

Insights

A child with Crohn's disease developed eosinophilic gastroenteritis due to bovine serum albumin (BSA) hypersensitivity. A meat-free diet resolved symptoms and normalized eosinophil counts, highlighting dietary triggers in pediatric inflammatory conditions.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Allergy

Background:

  • Crohn's disease (a chronic inflammatory bowel disease) can present with symptoms overlapping other gastrointestinal disorders in children.
  • Differentiating between Crohn's disease and other conditions with similar presentations is crucial for accurate diagnosis and treatment.

Observation:

  • A pediatric patient initially diagnosed with Crohn's disease presented with symptoms suggestive of eosinophilic gastroenteritis.
  • Distinct laboratory findings, including marked peripheral blood eosinophilia (7,476 cells/mm³) and elevated serum IgE (1,050 kU/L), were noted.
  • Radiographic and histological evaluations further supported a diagnosis separate from Crohn's disease.

Findings:

  • Eosinophilic gastroenteritis was confirmed and attributed to bovine serum albumin (BSA) hypersensitivity.
  • Diagnostic confirmation included skin prick tests, specific IgE serum levels, and SDS-PAGE IgE-immunoblotting.
  • A strict meat-free diet led to symptom resolution and a decrease in eosinophil count within twelve months.

Implications:

  • This case underscores the importance of considering allergic triggers, such as BSA hypersensitivity, in pediatric inflammatory bowel conditions.
  • Accurate differentiation between Crohn's disease and eosinophilic gastroenteritis is vital for effective therapeutic strategies.
  • Dietary interventions can be highly effective in managing specific types of pediatric eosinophilic gastroenteritis.

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