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[Expression of CD117 antigen on multiple myeloma and its significance]

Juan Li1, Shao-Kai Luo, Guo-Cai Zhang

  • 1Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. luliyuan@163.net

AI Zheng = Aizheng = Chinese Journal of Cancer
|August 11, 2004
PubMed
Abstract

Insights

CD117 is expressed on multiple myeloma cells, potentially serving as a target for tyrosine kinase inhibitors. This antigen

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Leukocyte differentiation antigen CD117 is a target for tyrosine kinase selective inhibitors.
  • CD117 expression levels correlate with the efficacy of these inhibitors.
  • Investigating CD117 expression in multiple myeloma (MM) may inform targeted therapy use.

Purpose of the Study:

  • To investigate the expression of CD117 on multiple myeloma cells.
  • To evaluate the significance of CD117 expression for potential tyrosine kinase inhibitor therapy in MM.

Main Methods:

  • Three-color flow cytometry was used to measure CD117, CD56, and CD54 expression.
  • A CD45/SSC gating strategy was employed for cell identification.
  • Analysis included 48 patients diagnosed with multiple myeloma.

Main Results:

  • CD117 was expressed on myeloma cells in 35.5% of MM patients.
  • CD117 expression correlated positively with the percentage of myeloma cells in bone marrow.
  • Higher CD117 expression was observed in the IgG subtype of MM compared to other types.

Conclusions:

  • CD117 is identified as a related tumor antigen in multiple myeloma.
  • CD117 expression may serve as a valuable marker for guiding the use of tyrosine kinase selective inhibitors in MM treatment.

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