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[Bronchial changes in untreated asthma].

C Delacourt1

  • 1Centre hospitalier intercommunal, 40, avenue de Verdun, 94000 Créteil, France. christophe.delacourt@chicreteil.fr <christophe.delacourt@chicreteil.fr>

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|August 11, 2004
PubMed
Summary
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Persistent asthma involves airway remodeling, leading to irreversible airway obstruction in children and adults. Early asthma treatment may prevent or limit this airway remodeling process.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Research
  • Cellular Biology

Context:

  • Persistent asthma is linked to airway remodeling, causing structural changes in bronchi.
  • This remodeling is poorly responsive to standard asthma therapies.
  • Airway remodeling contributes significantly to persistent airway obstruction and loss of reversibility in asthmatic patients, including children.

Purpose:

  • To investigate the role of airway remodeling in persistent asthma.
  • To understand the early onset and progression of airway remodeling in asthma development.
  • To explore the potential of early treatment in preventing or limiting airway remodeling.

Summary:

  • Airway remodeling, characterized by structural bronchial changes, is a key feature of persistent asthma.

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  • This process is evident even in pediatric asthma and not exclusive to severe, long-standing cases.
  • Evidence suggests airway remodeling begins early in asthma development and may be influenced by early interventions.

    • Impact:

    • Highlights the significance of airway remodeling in asthma pathophysiology.
    • Underscores the need for early diagnosis and intervention in pediatric asthma.
    • Suggests potential therapeutic strategies targeting airway remodeling for improved asthma management.