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Apoptotic/mytogenic pathways during human heart development.

Paolo Fiorina1, Domenico Corradi, Silvana Pinelli

  • 1Department of Medicine, San Raffaele Scientific Institute (HSR), Milan, Via Olgettina 60, Milan 20132, Italy. paulo.fiorina@hsr.it

International Journal of Cardiology
|August 11, 2004
PubMed
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During human heart development, myocytes undergo apoptosis and mitosis. Shc isoforms and ERK signaling are crucial for maintaining heart homeostasis, with changes observed during gestation.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Molecular Cardiology

Background:

  • Heart development involves dynamic cellular processes like apoptosis and mitosis.
  • Intracellular signaling pathways play critical roles in regulating these developmental events.
  • Understanding these pathways is essential for comprehending normal heart formation and potential pathologies.

Purpose of the Study:

  • To investigate myocyte apoptosis/mitosis during human heart development.
  • To identify and characterize associated intracellular signaling pathways.
  • To explore the role of specific signaling molecules in cardiac homeostasis.

Main Methods:

  • Histological and molecular analysis of human fetal hearts across different gestation ages.
  • Analysis of human adult hearts (normal and pathological) as controls.

Related Experiment Videos

  • Examination of Shc isoforms, ERK, JNK, and CD95 expression and activation.

    • Main Results:

    • All Shc isoforms are expressed and activated in the fetal heart, with expression fading during gestation.
    • ERK expression also decreases with gestation, while JNK is present but not activated.
    • Apoptotic/proliferative processes and CD95 expression are prominent in early gestation and decrease over time.
    • A 55 kD Shc isoform is identified and upregulated in adult myocardial ischemia.

    Conclusions:

    • Myocyte apoptosis and mitosis are integral to human heart development during gestation.
    • Shc isoforms and ERK signaling are key regulators of cardiac homeostasis.
    • The 55 kD Shc isoform may be relevant in adult myocardial ischemia.