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Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion
Koen K A Van Rompay1, Marta L Marthas, Norbert Bischofberger
1California National Primate Research Center, University of California, Davis, CA 95616, USA. kkvanrompay@ucdavis.edu
Antiviral Research
|August 11, 2004
Abstract:
We investigated if the antiviral drug tenofovir has immunomodulatory effects in macaques, similar to those described in murine models. While in vivo experiments were complicated by high individual and temporal variability of immune parameters, tenofovir primed macaque peripheral blood mononuclear cells in vitro for enhanced IL-12 secretion following exposure to bacterial antigens.
