Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subfunctionalization: How often does it occur? How long does it take?

Rachel Ward1, Richard Durrett

  • 1University of Texas, Austin, USA.

Theoretical Population Biology
|August 11, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal trade-offs shape metabolomic and proteomic responses to Varroa destructor parasitisation in honey bees (Apis mellifera).

Insect biochemistry and molecular biology·2026
Same author

Designing an effective fall preparedness and recovery program for older adults: an e-Delphi study.

BMC geriatrics·2026
Same author

Prenatal Cannabis Use and Neonatal Outcomes: A Systematic Review and Meta-Analysis.

Obstetrical & gynecological survey·2026
Same author

In Their Own Words: A Qualitative Exploration of Veterans' Perspectives and Experiences of Medical Cannabis Use.

Journal of general internal medicine·2026
Same author

Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.

Nature communications·2025
Same author

Age and Postural Stability in Firefighters: An Analysis of Anterior Reach Asymmetry and the Two-Foot Length Criterion.

International journal of exercise science·2025
Same journal

Statistical test to compare the linkage model and the admixture model based on central limit results.

Theoretical population biology·2026
Same journal

Threshold dynamics in age-structured distributions with expanding support: A unified mathematical framework.

Theoretical population biology·2026
Same journal

Mechanistic-statistical model for the expansion of ash dieback.

Theoretical population biology·2026
Same journal

Dynamics of an intraguild predation system with optimal foraging and harvesting.

Theoretical population biology·2026
Same journal

Impact of co-occurrent assortative mating and vertical cultural transmission on measures of genetic associations.

Theoretical population biology·2026
Same journal

The coalescent of a sample from a linear-fractional branching process.

Theoretical population biology·2026
See all related articles

Duplicate genes can be preserved through subfunctionalization, where gene copies specialize in complementary roles. This study explores the probability, timing, and influencing factors like population size and mutation rates for this evolutionary mechanism.

Area of Science:

  • Evolutionary biology
  • Genetics
  • Molecular biology

Background:

  • The long-standing debate on gene duplication preservation mechanisms.
  • Introduction of subfunctionalization as a novel explanation by Lynch and Force.
  • Subfunctionalization posits specialization of duplicated gene copies for complementary functions.

Purpose of the Study:

  • To investigate the probability of subfunctionalization occurring after gene duplication.
  • To determine the timeframe for resolution of functional outcomes post-duplication.
  • To analyze the influence of population size and mutation rates on subfunctionalization.

Main Methods:

  • Theoretical modeling of gene duplication and divergence.
  • Population genetics simulations.

Related Experiment Videos

  • Analysis of evolutionary trajectories under varying parameters.

    • Main Results:

    • Quantification of subfunctionalization probability under different conditions.
    • Estimation of the time required for functional resolution.
    • Identification of key relationships between population size, mutation rates, and subfunctionalization outcomes.

    Conclusions:

    • Subfunctionalization is a viable mechanism for preserving duplicate genes.
    • Population size and mutation rates significantly impact the likelihood and speed of subfunctionalization.
    • Provides quantitative insights into a major evolutionary process.