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[Changes in cutaneous zinc during skin aging].

B Dreno1, M Trossaert, H L Boiteau

  • 1Clinique Dermatologique, Hôtel Dieu, Nantes.

Annales De Dermatologie Et De Venereologie
|January 1, 1992
PubMed
Summary

Epidermal zinc concentration significantly decreases with aging in healthy adults. This reduction in zinc may contribute to age-related changes in skin cells (keratinocytes).

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Area of Science:

  • Dermatology
  • Biochemistry
  • Gerontology

Background:

  • Zinc is an essential trace element vital for numerous biological processes, including skin health.
  • Age-related changes in skin composition and function are well-documented.
  • Understanding nutrient variations with age is crucial for maintaining skin integrity.

Purpose of the Study:

  • To investigate the relationship between aging and epidermal zinc concentration.
  • To determine if epidermal zinc levels differ between younger and older healthy adults.
  • To explore the potential implications of these variations for skin aging.

Main Methods:

  • Healthy subjects were divided into two groups: younger (<35 years) and older (>65 years).
  • Epidermal samples were obtained using suction blistering.
  • Zinc levels in epidermal tissue were quantified using absorption spectrophotometry.

Main Results:

  • A statistically significant decrease (p<0.01) in epidermal zinc concentration was observed with aging.
  • Epidermal zinc levels were consistent between males and females across age groups.
  • Zinc levels in blister fluid did not differ between age groups, indicating no correlation with plasma zinc.

Conclusions:

  • Aging is associated with a decline in epidermal zinc concentration.
  • This reduction in zinc may impair epidermal enzyme activities, potentially contributing to keratinocyte alterations.
  • Zinc plays a significant role in age-related changes within the epidermis.

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