Related Experiment Video
Updated: Aug 23, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein (a) and its immune complexes in dyslipidemic subjects
Junjun Wang1, Chunni Zhang, Daning Chen
1Department of Biochemistry, Jinling Hospital, Clinical School of Medicine College, Nanjing University, Nanjing, PR China. wangjj6@jlonline.com
Objectives:
To investigate plasma levels of lipoprotein (a) [Lp(a)] and low-density lipoprotein (LDL)-circulating immune complexes (IC) in subjects with various dyslipidemias.
Methods:
Plasma Lp(a), Lp(a)-IC, and LDL-IC levels were determined by enzyme-linked immunosorbent assays (ELISAs) in 198 subjects with various dyslipidemias and 34 control subjects.
Results:
Hypertriglyceridemic subjects exhibited the lowest plasma Lp(a) levels, while hypercholesterolemic subjects exhibited the highest levels. Subjects with mixed hyperlipidemia had intermediate plasma Lp(a) concentrations, which were significantly lower than those of subjects with normal lipid levels. Interestingly, we also found that hypertriglyceridemic subjects had the lowest plasma Lp(a)-IC and LDL-IC levels, while hypercholesterolemic subjects exhibited the highest levels. Triglyceride (TG) levels were negatively correlated with Lp(a) (r = -0.15, P < 0.05), Lp(a)-IC (r = -0.20, P < 0.01), and LDL-IC (r = -0.214, P < 0.01) concentrations. Furthermore, significantly positive relationships were found between Lp(a)-IC and Lp(a) levels (r = 0.65, P < 0.001) and between LDL-IC and LDL-C levels (r = 0.43, P < 0.001).
Conclusions:
The results argue for a regulatory role of TG on plasma Lp(a) and its circulating immune complexes in subjects with various dyslipidemias. The circulating levels of these immune complexes levels are likely to change with different concentrations of Lp(a) and LDL.
Related Concept Videos
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Lipids: Dietary Sources and Requirements
Cholesterol: Significance and Regulation
Considering cholesterol and...
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...