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[Experimental studies on antitumor effects of endogenously induced LAK (CTL) therapy for metastatic liver tumor]
N Kaneda1, S Saji, T Kashizuka
12nd Dept. of Surgery, Gifu University School of Medicine.
Unlabelled:
Antitumor effects of endogenously induced LAK (CTL) therapy by trans-hepatic arterial administration with OK-432 and rIL-2 for metastatic liver tumor were examined.
Results:
The number of metastatic nodules (NMN) showed a significant correlation with the number of inoculated tumor cells. NMN of the treated group was significantly reduced over that of the saline group in cases of 2.5 x 10(6) VX2 cells inoculation, while the survival day showed no prolongation even in the treated group. On the other hand, when 1 x 10(5) tumor cells were inoculated the survival day was slightly more prolonged in the treated group than in the saline group. The PHA-induced blastogenesis of peripheral blood was significantly increased at 10 days after the therapy in case of non-tumor bearer, while in cases of tumor bearer it was decreased at 7 days after the therapy.