[Intra-arterial infusion chemotherapy in locally recurrent breast cancer]

Intra-arterial infusion chemotherapy (IA) using implantable reservoir was performed in four locally recurrent breast cancers. The regimen consisted of several cycles of induction (1 cycle, 90-150mg: EPI) and the following maintenance infusion. The results were as follows. (1) D.F.I. of all cases were short and pre-treatment of 3 cases was not effective. (2) Clinical response was 2 CR and 1 MR. We confirmed that IA was an effective treatment for not only locally recurrence but also disseminated foci. (3) In 3 out of the four cases there was reduction of severe arm swelling. These findings suggested that IA using implantable reservoir was useful for the treatment of locally recurrent breast cancer in terms of anti-cancer effect and improved QOL.