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Updated: Aug 23, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
Published on: March 29, 2024
Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure
1The Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew's and The Royal London School of Medicine and Dentistry, London. c.thiemermann@qmul.ac.uk
Abstract:
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce myocardial tissue injury and infarct size. The use of PPAR-gamma agonists in the treatment of heart failure is, however, controversial.
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