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[Targeting cancer chemotherapy using temperature-sensitive liposomes containing adriamycin conjugated with monoclonal
S Shibata1, K Kumai, T Takahashi
1Dept. of Surgery, School of Medicine, Keio University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1992
Abstract:
Liposomes have a specific liquid-crystalline phase transition temperature (Tc), at which they release an entrapped drug. Temperature-sensitive liposomes containing adriamycin (TS-Lip-ADM) were made of dipalmitoylphosphatidylcholine (DPPC, Tc: 41 degrees C), distearoylphosphatidylcholine (DSPC, Tc: 54 degrees C), cholesterol and adriamycin. Monoclonal antibodies against human alpha-fetoprotein (AFP) were conjugated to TS-Lip-ADM. When liposomal suspension was immersed in a bath, the release rate of ADM from TS-Lip-ADM = Ab increased, as the temperature increased from 34 degrees C to 42 degrees C. ADM release was dependent on the temperature.