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Updated: Jul 15, 2026

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
Published on: December 1, 2014
Comparing biofilm models for a single species biofilm system
E Morgenroth1, H J Eberl, M C M van Loosdrecht
1Department of Civil and Environmental Engineering and Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. emorgenr@uiuc.edu
Abstract:
A benchmark problem was defined to evaluate the performance of different mathematical biofilm models. The biofilm consisted of heterotrophic bacteria degrading organic substrate and oxygen. Mathematical models tested ranged from simple analytical to multidimensional numerical models. For simple and more or less flat biofilms it was shown that analytical biofilm models provide very similar results compared to more complex numerical solutions. When considering a heterogeneous biofilm morphology it was shown that the effect of an increased external mass transfer resistance was much more significant compared to the effect of an increased surface area inside the biofilm.

