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Published on: August 7, 2017
Indoor exposures and recurrent wheezing in infants: a study in the BAMSE cohort
G Emenius1, M Svartengren, J Korsgaard
1Department of Occupational and Environmental Health, Stockholm County Council, Sweden. gunnel.emenius@smd.sll.se
Insights
Indoor dampness and newly painted surfaces are linked to recurrent infant wheezing. Multiple dampness indicators significantly increase the risk, suggesting combined indoor exposures worsen outcomes.
Area of Science:
- Environmental Health
- Pediatric Respiratory Medicine
- Epidemiology
Background:
- Recurrent wheezing in infancy is a significant health concern.
- Indoor environmental factors are suspected contributors to infant respiratory illnesses.
Purpose of the Study:
- To investigate the association between indoor environmental exposures and the development of recurrent wheezing in infants.
- To determine the impact of dampness and recently painted surfaces on infant respiratory health.
Main Methods:
- A birth cohort of 4089 children was followed.
- A nested case-control study involved 181 infants with recurrent wheezing and 359 controls.
- Home inspections assessed indoor conditions, including dampness and paint status.
Main Results:
- Parent-reported and observed dampness were associated with increased odds of recurrent infant wheezing (OR 1.4-1.6).
- A dose-response relationship was observed, with three or more signs of dampness increasing the risk (OR 2.7).
- Newly painted surfaces in the bedroom were linked to a higher risk of recurrent wheezing (OR 1.7).
Conclusions:
- Indoor dampness indicators are associated with recurrent infant wheezing.
- Recently repainted interior surfaces may also contribute to infant wheezing.
- Combined indoor exposures appear to strengthen the risk of recurrent wheezing in infants.
Aim:
The aim of this study was to examine the relationship between indoor exposures and the home environment, and the development of recurrent wheezing during infancy.
Methods:
A birth cohort, comprising 4089 children, was followed. Information on exposures was obtained shortly after birth, and episodes of wheezing were recorded when the infants were 1 and 2 y of age. In a nested case-control study, 181 infants were enrolled, who had three or more reported episodes of wheezing after 3 mo of age combined with either use of inhaled steroids or symptoms of bronchial hyper-reactivity, and 359 age-matched controls. Home inspections were performed during the winter following enrolment, and indoor conditions were measured.
Results:
Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated. The OR for recurrent infant wheezing associated with signs of dampness reported prospectively by parents was 1.4 (0.9-2.2), and the OR for observed signs of dampness at home inspections was 1.6 (1.0-2.5). A trend was found in the risk of recurrent wheezing in relation to the number of indicators of dampness: OR 1.3 (0.8-2.2) for one sign of dampness and OR 2.7 (1.3-5.4) for three or more signs of dampness. Newly painted surfaces in the child's bedroom was associated with an increased OR for recurrent wheezing: 1.7 (1.3-2.6).
Conclusion:
Indicators of dampness, as well as recently repainted interior surfaces, appear to be associated with recurrent infant wheezing, with a strengthened effect of combined indoor exposures.
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