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Lactate in the foetal brain: detection and implications.

Ariadne M Roelants-van Rijn¹, Floris Groenendaal, Philip Stoutenbeek

¹Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.

Acta Paediatrica (Oslo, Norway : 1992)

|August 12, 2004

Summary

Proton magnetic resonance spectroscopy (1H-MRS) can detect fetal brain lactate in vivo. Adequate fetal immobilization is crucial for successful lactate detection in hydrocephalic fetuses.

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Area of Science:

Biomedical imaging
Fetal medicine
Neuroscience

Background:

Hydrocephalus affects fetal brain development.
Lactate accumulation can indicate metabolic distress in the fetal brain.

Purpose of the Study:

To assess the feasibility of detecting fetal brain lactate using proton magnetic resonance spectroscopy (1H-MRS).
To evaluate 1H-MRS for in vivo lactate detection in hydrocephalic fetuses.

Main Methods:

Proton magnetic resonance spectroscopy (1H-MRS) was performed on six hydrocephalic fetuses (29-38 weeks gestational age).
Spectroscopy targeted the basal ganglia region for lactate detection.
Fetal immobilization techniques were employed.

Main Results:

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Lactate was detected in the brains of two fetuses.
Lactate was absent in two fetuses.
Image quality was compromised by fetal movement in two cases, preventing lactate detection.

Conclusions:

Proton magnetic resonance spectroscopy (1H-MRS) is a viable method for in vivo fetal brain lactate detection.
Successful detection of fetal lactate using 1H-MRS is dependent on adequate fetal immobilization.