[Experimental model of liver metastases of the mouse]

3 syngeneic tumor-mouse systems were used to establish experimental model of liver metastasis. Only one system, SC42-DS, was suitable for the purpose. When 2 x 10(5) SC42 tumor cells was injected into the spleen of DS mouse and splenectomy was done after 24 hours preventing of spleen tumor due to implantation, multiple nodular liver metastasis were observed in all mice after 14 days. The numbers of nodulus were well correlated with the liver weight.