[Prevention of mouse liver metastases by perioperative immunostimulation using OK-432]

Two surgical procedures were required to make experimental model of liver metastasis (SC42-DS). In this paper, the protective effects of OK432 against liver metastasis were examined experimentally, as a immunotherapeutic agent under perioperative condition. In 5 combinations of administration, OK432 showed some different effects on liver metastasis, however, in general, simultaneous intrasplenic injection of OK432 reduced liver metastasis. From this result, the efficacy of intraoperative OK432 via portal vein was speculated.