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Related Experiment Videos

Systemic and local ibandronate enhance screw fixation.

Björn Skoglund1, Jonas Holmertz, Per Aspenberg

  • 1Division of Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University Hospital, Linkoping SE-581 85, Sweden.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|August 12, 2004
PubMed
Summary

Bisphosphonate treatment, either systemic or local, significantly enhanced early implant fixation in rat tibiae by inhibiting bone resorption. This suggests bisphosphonates are a promising pharmacological approach to improve screw stability after bone implantation.

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Pharmacology

Background:

  • Implant insertion triggers inflammatory responses and osteoclast activation, potentially impairing early bone fixation.
  • Osteocyte apoptosis further exacerbates osteoclast activity, tipping the balance towards resorption.
  • Bisphosphonates are known to inhibit bone resorption, making them potential candidates to improve implant osseointegration.

Purpose of the Study:

  • To investigate the efficacy of bisphosphonates in improving early implant fixation.
  • To evaluate both systemic and local administration of ibandronate on screw stability in bone.

Main Methods:

  • Stainless steel screws were implanted into rat tibiae.
  • Rats received daily subcutaneous injections or local application of ibandronate or saline.

Related Experiment Videos

  • Mechanical testing (pull-out strength, torque resistance) and histology were performed after 14 days.

    • Main Results:

    • Systemic ibandronate increased pull-out force by 30% (p=0.04).
    • Local ibandronate increased pull-out force by 15% (p=0.02) and stiffness by 28% (p=0.01).
    • Local treatment significantly improved torque resistance and friction, indicating enhanced mechanical stability.

    Conclusions:

    • Early bone remodeling significantly influences screw fixation.
    • Systemic or local bisphosphonate administration can effectively improve early implant fixation.
    • Bisphosphonates represent a viable pharmacological strategy to enhance bone implant stability.