Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomewide expression analysis in amino acid-producing bacteria using DNA microarrays.

Tino Polen1, Volker F Wendisch

  • 1Institute of Biotechnology 1, Research Center Jülich, Leo-Brandt-Str, D-52428, Germany.

Applied Biochemistry and Biotechnology
|August 12, 2004
PubMed
Summary

DNA microarrays enable whole-genome analysis of gene expression in bacteria like Escherichia coli and Corynebacterium glutamicum, advancing amino acid production research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperativity in microbial biotechnology: synthetic consortia as emerging metabolic engineering strategy for sustainable bioproduction.

Frontiers in bioengineering and biotechnology·2026
Same author

Engineering of Corynebacterium glutamicum for biosynthesis of the pharmaceutically active N-acetyltyramine: establishing and optimizing de novo production.

Journal of biological engineering·2026
Same author

Design and validation of an inducible and curable EvolvR system for directed evolution in <i>Corynebacterium glutamicum</i>.

Frontiers in bioengineering and biotechnology·2026
Same author

Expanding the substrate spectrum in engineered Pseudomonas taiwanensis for efficient production of 4-coumarate from lignocellulosic sugars.

Microbial cell factories·2026
Same author

Efficient Coutilization of Methanol with Pentose Sugars by Engineered <i>Corynebacterium glutamicum</i> for Protocatechuic Acid Production.

Journal of agricultural and food chemistry·2026
Same author

Exploring the bifunctionality of aminotransferases in the arogenate route of l-tyrosine synthesis.

Journal of biomolecular structure & dynamics·2025

Area of Science:

  • Genomics
  • Microbiology
  • Biotechnology

Background:

  • DNA microarray technology allows for genome-wide characterization of genetic diversity and gene expression.
  • Applications in Escherichia coli are extensive, but recent development for Corynebacterium glutamicum is notable.
  • Both bacteria are crucial for biotechnological amino acid production.

Purpose of the Study:

  • To describe the design, generation, and application of DNA microarrays for bacterial studies.
  • To highlight recent applications in amino acid production using Corynebacterium glutamicum and Escherichia coli.
  • To discuss the impact of functional genomics on amino acid production.

Main Methods:

  • Design and generation of DNA microarrays.
  • Hybridization experiments for gene expression analysis.

Related Experiment Videos

  • Bioinformatic analysis of microarray data.

    • Main Results:

    • DNA microarrays provide a powerful tool for studying bacterial biology at a genomic scale.
    • Recent applications demonstrate the utility of microarrays for optimizing amino acid production in C. glutamicum and E. coli.
    • Functional genomics studies significantly impact fundamental and applied aspects of amino acid biosynthesis.

    Conclusions:

    • DNA microarrays are essential for advancing our understanding of bacterial gene expression and function.
    • This technology is pivotal for improving biotechnological processes, particularly in amino acid production.
    • Future research will likely leverage functional genomics to further enhance microbial production systems.