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Updated: Aug 23, 2026
Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
Published on: July 16, 2012
Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by
Haruhiro Fujimoto1, Etsuko Nakamura, Emi Okuyama
1Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan. fujimoto@p.chiba-u.ac.jp
Abstract:
In a screening study on immunomodulatory fungal metabolites, three known anthraquinones, carviolin (roseo-purpurin) (1), 1-O-methylemodin (2), omega-hydroxyemodin (citreorosein) (4), and a new anthraquinone, omega-acetylcarviolin (3), together with a known steroid, ergosta-4,6,8(14),22-tetraen-3-one (5) and a new steroid, 25-hydroxyergosta-4,6,8(14),22-tetraen-3-one (6) were isolated from an Ascomycete, Zopfiella longicaudata, and found to have moderate immunosuppressive activities. The structure-activity relationships of these metabolites are discussed.
