Hot topics in phospholipase A2 field
1Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. mako@pharm.showa-u.ac.jp
Abstract:
As detailed in previous reviews, phospholipase A2 (PLA2) enzymes belonging to the secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and Ca2+-independent PLA2 (iPLA2) families may play specific physiologic and pathologic roles. In the past two years, there have been considerable advances in the understanding of the regulatory functions of individual PLA2s. This short article focuses on the latest topics in the PLA2 field, which have offered new insights into this intriguing enzyme family. Specifically, I describe a novel cellular action and unexplored in vivo functions of sPLA2, expanding regulatory aspects of cPLA2, and unique functional roles of iPLA2 in apoptosis, Ca2+ homeostasis, and myocardial ischemia.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Protein Kinases and Phosphatases
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
IP3/DAG Signaling Pathway
Synthesis of Phosphatidylcholine in the ER Membrane
The major components of all eukaryotic cell...
Amplifying Signals via Second Messengers
Asymmetric Lipid Bilayer


