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Mammalian artificial chromosomes: modern day feats of engineering--Isambard Kingdom Brunel style

J M Bridger1

  • 1Laboratory of Nuclear and Genomic Health, Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, West London, UK. Joanna.bridger@brunel.ac.uk

Cytogenetic and Genome Research
|August 12, 2004
PubMed
Abstract

No abstract available in PubMed .

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Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...