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Related Experiment Videos

Congenital abdominal wall defects: an update.

R Douglas Wilson1, Mark P Johnson

  • 1Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399, USA. wilsonrd@email.chop.edu

Fetal Diagnosis and Therapy
|August 12, 2004
PubMed
Summary

This review covers gastroschisis and omphalocele, common congenital abdominal wall defects. These conditions are associated with significant infant morbidity and mortality, necessitating careful management.

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The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation.

Birth defects research·2026

Area of Science:

  • Pediatric Surgery
  • Neonatal Medicine
  • Medical Genetics

Background:

  • Gastroschisis and omphalocele are congenital anomalies affecting the abdominal wall.
  • These defects present unique challenges in diagnosis and management.
  • Understanding their epidemiology and outcomes is crucial for clinical practice.

Purpose of the Study:

  • To conduct a comprehensive review of the peer-reviewed literature on gastroschisis and omphalocele.
  • To synthesize current knowledge on the pathology, incidence, and management of these conditions.
  • To highlight areas for potential fetal therapy and improved outcomes.

Main Methods:

  • Literature search of Medline database from 1985 to 2003.
  • Inclusion of relevant textbook information.

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  • Systematic review of published peer-reviewed studies.

    • Main Results:

    • Review encompasses pathology, incidence, epidemiology, prenatal diagnosis, and management strategies.
    • Discussion includes postnatal outcomes and the potential for fetal therapeutic interventions.
    • Data synthesis provides a broad overview of current understanding.

    Conclusions:

    • Gastroschisis and omphalocele are prevalent abdominal wall defects with considerable associated morbidity and mortality.
    • Effective management requires a multidisciplinary approach from prenatal diagnosis through postnatal care.
    • Further research into fetal therapies may improve long-term outcomes.