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Congenital abdominal wall defects: an update

R Douglas Wilson1, Mark P Johnson

  • 1Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399, USA. wilsonrd@email.chop.edu

Fetal Diagnosis and Therapy
|August 12, 2004
PubMed

Insights

This review covers gastroschisis and omphalocele, common congenital abdominal wall defects. These conditions are associated with significant infant morbidity and mortality, necessitating careful management.

Area of Science:

  • Pediatric Surgery
  • Neonatal Medicine
  • Medical Genetics

Background:

  • Gastroschisis and omphalocele are congenital anomalies affecting the abdominal wall.
  • These defects present unique challenges in diagnosis and management.
  • Understanding their epidemiology and outcomes is crucial for clinical practice.

Purpose of the Study:

  • To conduct a comprehensive review of the peer-reviewed literature on gastroschisis and omphalocele.
  • To synthesize current knowledge on the pathology, incidence, and management of these conditions.
  • To highlight areas for potential fetal therapy and improved outcomes.

Main Methods:

  • Literature search of Medline database from 1985 to 2003.
  • Inclusion of relevant textbook information.
  • Systematic review of published peer-reviewed studies.

Main Results:

  • Review encompasses pathology, incidence, epidemiology, prenatal diagnosis, and management strategies.
  • Discussion includes postnatal outcomes and the potential for fetal therapeutic interventions.
  • Data synthesis provides a broad overview of current understanding.

Conclusions:

  • Gastroschisis and omphalocele are prevalent abdominal wall defects with considerable associated morbidity and mortality.
  • Effective management requires a multidisciplinary approach from prenatal diagnosis through postnatal care.
  • Further research into fetal therapies may improve long-term outcomes.
Abstract

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