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Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome

Yong Tian1, Mingyuan Li, Bernd Fritzsch

  • 1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|August 12, 2004
PubMed

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.