Related Experiment Video
Updated: Aug 23, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Pycnogenol accelerates wound healing and reduces scar formation
G Blazsó1, M Gábor, F Schönlau
1Department of Pharmacodynamics and Biopharmacy, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Hungary. blazso@pharma.szote.uszeged.hu
Abstract:
Pycnogenol was applied topically to experimental wounds inflicted on healthy rats by means of a branding iron. The wound-healing time was taken as the number of days required for 50% of the scabs to separate spontaneously from the animals. Application of a gel formulation containing 1% Pycnogenol significantly shortened the wound healing time, by 1.6 days compared with the group treated with gel only (15.4 days). The application of 2% Pycnogenol decreased the healing time by almost 3 days, while 5% Pycnogenol further accelerated the wound-healing process. In parallel, Pycnogenol gels reduced the diameter of the scars remaining following complete scab loss in a concentration-dependent manner. In conclusion, Pycnogenol is a potent active ingredient for the treatment of minor injuries.
Related Concept Videos
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clinical Applications of Epidermal Stem Cells
Healing II: Complications
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
