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Published on: November 25, 2025
A new surgical approach for indocyanine green-assisted internal limiting membrane peeling
Remzi Avci1, Berrin Avci, Berkant Kaderli
1Department of Ophthalmology, Uludag University Hospital, Bursa, Turkey.
Background And Objective:
The efficiency of indocyanine green (ICG) dye in the removal of the internal limiting membrane (ILM) with a fluid needle using passive aspiration was evaluated.
Patients And Methods:
Eighteen consecutive patients with diffuse diabetic macular edema were studied. After vitrectomy and total fluid-air exchange, 0.1 mL of ICG solution 0.25% was left in the macular area for 1 minute. Then the macular ILM was peeled with a specially designed tapered fluid needle using passive aspiration.
Results:
In 16 of the 18 eyes, the peeling procedure could be easily performed with a tapered fluid needle using passive aspiration. In 11 eyes, partial development of spontaneous ILM detachment prior to the peeling process was also observed.
Conclusions:
ICG solution 0.25% appears to reduce the adhesive force of the ILM to the sensory retina, which makes the removal of the ILM much easier by passive aspiration with a fluid needle.