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Related Experiment Videos

Morphine state-dependent learning: sensitization and interactions with dopamine receptors.

Mohammad-Reza Zarrindast1, Ameneh Rezayof

  • 1Department of Pharmacology, School of Medicine Tehran University of Medical Sciences, P. O. Box 13145-784, Tehran, Iran. zarinmr@ams.ac.ir

European Journal of Pharmacology
|August 13, 2004
PubMed
Summary

Morphine sensitization impairs memory formation but not retrieval in mice. Dopamine receptor antagonists reversed morphine-induced amnesia, suggesting their role in morphine

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Opioid drugs like morphine can affect cognitive functions, including memory formation and retrieval.
  • Morphine sensitization, a phenomenon where repeated exposure leads to amplified effects, may alter these cognitive impacts.
  • Understanding these effects is crucial for managing pain and potential cognitive side effects of opioid therapy.

Purpose of the Study:

  • To investigate how morphine sensitization influences memory impairment and state-dependent learning in mice.
  • To explore the role of dopamine receptors in morphine-induced memory alterations.
  • To determine if sensitization alters the amnesic or retrieval-facilitating effects of morphine.

Main Methods:

  • Mice were subjected to a passive avoidance task to assess learning and memory.

Related Experiment Videos

  • Morphine administration before training (pretraining) or testing (pretest) was used to induce amnesia and state-dependent learning.
  • Morphine sensitization was induced through repeated daily injections.
  • Naloxone, dopamine receptor agonists (SKF 38393, quinpirole), and antagonists (SCH 23390, sulpiride) were administered to investigate their effects on morphine-induced memory changes.

    • Main Results:

    • Pretraining morphine dose-dependently impaired memory formation.
    • Pretest morphine induced state-dependent retrieval of memories.
    • Morphine sensitization significantly reversed morphine-induced amnesia.
    • Sensitization did not significantly affect morphine-induced state-dependent memory.
    • Dopamine receptor antagonists (SCH 23390) and agonists (quinpirole) modulated morphine-induced amnesia, while others (SKF 38393, sulpiride) showed mixed effects.

    Conclusions:

    • Morphine sensitization impacts the impairment of memory formation but not the facilitation of retrieval.
    • Dopamine receptors appear to play a significant role in the effects of morphine sensitization on memory.
    • These findings contribute to understanding the complex interplay between opioid exposure, sensitization, and cognitive function.