Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-assembly using dynamic combinatorial chemistry.

Jeremy K M Sanders1

  • 1University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. jkms@cam.ac.uk

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|August 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chirality-Assisted Self-Assembly of Low-Symmetry Noncovalent Capsules with Quantitative Diastereoisomeric Selection.

Journal of the American Chemical Society·2025
Same author

A Multistate Adaptive System of Topologically Distinct Chiral Assemblies.

Angewandte Chemie (International ed. in English)·2025
Same author

Solvation rules: aromatic interactions outcompete cation-π interactions in synthetic host-guest complexes in water.

Chemical communications (Cambridge, England)·2023
Same author

Aromatic interactions with heterocycles in water.

Chemical science·2023
Same author

Substituent effects on aromatic interactions in water.

Chemical science·2023
Same author

What has <i>Royal Society Open Science</i> achieved in its first few years?

Royal Society open science·2021
Same journal

Correction to: 'Stokes settling and particle-laden plumes: implications for deep-sea mining and volcanic eruption plumes' (2020), by Mingotti et al.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

A stable hothouse triggered by a tipping mechanism.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Beyond distance: quantifying point cloud dynamics with persistent homology and dynamic optimal transport.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Global stability of the Atlantic overturning circulation: edge state, long transients and boundary crisis under CO2 forcing.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Morse index classification and landscape of Kuramoto system for Hebbian-based binary pattern recognition.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Interpretable and equation-free response theory for complex systems.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
See all related articles

This study introduces an evolution-selection method for creating molecular recognition systems. Dynamic combinatorial self-assembly successfully synthesized various synthetic receptors using reversible chemistries.

Area of Science:

  • Supramolecular Chemistry
  • Chemical Synthesis
  • Molecular Recognition

Background:

  • Developing synthetic systems capable of specific molecular recognition is a significant challenge in chemistry.
  • Traditional synthesis methods may lack the adaptability required for complex recognition tasks.

Purpose of the Study:

  • To describe an evolution-selection approach for synthesizing molecular recognition systems.
  • To demonstrate the utility of dynamic combinatorial self-assembly in creating synthetic receptors.

Main Methods:

  • Utilizing dynamic combinatorial self-assembly in bulk solution.
  • Employing reversible chemistries such as metalloporphyrin-ligand coordination, hydrazone exchange, and disulfide exchange.

Main Results:

Related Experiment Videos

  • Successful synthesis of a variety of synthetic receptors.
  • Demonstration of the feasibility of the evolution-selection strategy for receptor design.

Conclusions:

  • The evolution-selection approach is effective for synthesizing molecular recognition systems.
  • Reversible chemistries are key to dynamic combinatorial self-assembly for receptor synthesis.
  • The approach shows potential for extension to surface-based applications.