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Related Experiment Videos

A physiologically based model of interaural time difference discrimination.

Kenneth E Hancock1, Bertrand Delgutte

  • 1Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. keh@epl.meei.harvard.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 13, 2004
PubMed
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Neural pooling across auditory neurons refines sound localization. A new model explains how pooling information from inferior colliculus cells improves interaural time difference (ITD) discrimination, especially for broadband noise.

Area of Science:

  • Auditory Neuroscience
  • Computational Neuroscience
  • Acoustic Signal Processing

Background:

  • Interaural time difference (ITD) is a crucial cue for low-frequency sound localization.
  • Cells in the inferior colliculus (IC) represent ITD with specific best delays (BD).
  • Previous models suggested single-cell ITD information was sufficient for midline localization.

Purpose of the Study:

  • To develop a neural pooling model for interaural time difference (ITD) discrimination.
  • To account for the degradation of ITD acuity with increasing ITD in human listeners.
  • To investigate the role of neuronal pooling in auditory spatial processing.

Main Methods:

  • A cross-correlation model was used to fit rate-versus-ITD curves of IC cells in anesthetized cats.

Related Experiment Videos

  • Parameters from single-cell models constrained a population model of ITD discrimination.
  • The model predicted ITD acuity for broadband noise and 500 Hz tones.

    • Main Results:

    • The neural pooling model accurately predicted human ITD acuity for broadband noise as a function of ITD.
    • Pooling responses across best frequency (BF) was essential for model accuracy.
    • Internal delay systems alone were insufficient to predict ITD acuity for pure tones.

    Conclusions:

    • Neuronal pooling across auditory neurons is critical for accurate ITD discrimination.
    • The model provides a framework for understanding how the brain processes spatial auditory information.
    • Observed systematic variation of BD with BF in cats generalizes findings across species.