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1,4-Dimethoxy-9(10H)-acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity
H Berny1, N Bsiri, J J Charbit
1Groupe d'Enseignement et de Recherce en Chimie, Thérapeutique Organique et Physique (GERCTOP), Faculté de Pharmacie, Université de Marseille, France.
Arzneimittel-Forschung
|May 1, 1992
Abstract:
New acridinonic derivatives, which are hydroxy- and methoxy-substituted in positions 1, 4, and 1,4 were prepared with a view to obtain antiparasitic drugs. These compounds were tested against Trypanosoma cruzi strains and their capability of interacalation into DNA was determined. Nucleus substitutions, DNA binding, and trypanocidal activities have been correlated.