Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Foot problems in diabetes: an overview.

Jan S Ulbrecht1, Peter R Cavanagh, Gregory M Caputo

  • 1Department of Biobehavioral Health, Pennsylvania State University, University Park, 16802, USA. jsu1@psu.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subject-specific material properties of the heel pad: An inverse finite element analysis.

Journal of biomechanics·2024
Same author

Risk factors for 30-day readmission in patients with congestive heart failure.

Heart & lung : the journal of critical care·2017
Same author

A preliminary study of patient-specific mechanical properties of diabetic and healthy plantar soft tissue from gated magnetic resonance imaging.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2017
Same author

Towards human exploration of space: the THESEUS review series on muscle and bone research priorities.

NPJ microgravity·2017
Same author

Replacement of daily load attenuates but does not prevent changes to the musculoskeletal system during bed rest.

Bone reports·2017
Same author

Randomized Face-to-Face vs. Home Exercise Interventions in Pregnant Women with Gestational Diabetes.

Psychology of sport and exercise·2017
Same journal

The balance between a new Antibiotic and Non-antibiotic Alternatives for the treatment and prevention of uncomplicated Urinary Tract Infections.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Understanding the Clone-Censor-Weight Method in Observational Studies of Antibiotic Duration.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Treatment of Progressive Multifocal Leukoencephalopathy with Third-Party Allogeneic BK Virus T Cells.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Protection Against Recurrent Typhoid Fever Conferred by a Prior Episode: Evidence from a Large Cohort Study in Dhaka, Bangladesh.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Pre-treatment Gut Microbiome Diversity and Function Linked to Cytotoxic and Natural Killer Cell Immune Responses after N-803 Treatment in People with HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Reconsidering ambiguous language in infectious disease consult recommendations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Diabetic foot ulcers, often caused by nerve damage, can be healed in about 6 weeks with proper mechanical off-loading. Annual screening for loss of protective sensation is crucial for preventing amputations.

Area of Science:

  • Podiatry
  • Diabetology
  • Vascular Surgery

Background:

  • Diabetes is the primary cause of non-traumatic lower-extremity amputations in the U.S.
  • Diabetic foot ulcers, predominantly neuropathic and plantar, precede most amputations and are costly.
  • These ulcers result from repetitive trauma at high-load areas due to loss of pain sensation.

Purpose of the Study:

  • To highlight the efficacy of mechanical off-loading in healing diabetic foot ulcers.
  • To emphasize the importance of preventive measures and early screening for high-risk diabetic patients.
  • To advocate for annual screening of protective sensation in all diabetic individuals.

Main Methods:

  • Mechanical off-loading, with total contact cast as the gold standard, effectively treats neuropathic plantar ulcers.

Related Experiment Videos

  • Approximately 90% of ulcers heal within 6 weeks when properly off-loaded in adequately perfused limbs.
  • Annual screening using the 10-g Semmes-Weinstein monofilament identifies patients with loss of protective sensation.

    • Main Results:

    • Proper mechanical off-loading leads to successful healing in about 90% of diabetic foot ulcers within 6 weeks.
    • Preventive strategies, including screening and education, can significantly reduce ulceration incidence.
    • Early detection of sensory loss allows for timely intervention and complication prevention.

    Conclusions:

    • Mechanical off-loading is a highly effective treatment for diabetic foot ulcers.
    • Preventive measures, including regular screening and patient education, are essential for reducing amputations.
    • Annual screening for loss of protective sensation is a vital component of diabetes care.