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[Inhibitive effect of Semen Cassiae on the weight gain in rats with nutritive obesity]
Yan Junbao1, Jin Long, Wang Jiangbi
1Lanzhou Medical College, Lanzhou 730000.
Objective:
To observe the effect of water extract of Semen Cassiae on the weight gain of nutritive obesity rat.
Methods:
Nutritive obesity model in rats was made by high nutritive diet. Various concentration water extracts of Semen Cassiae were drunk by the rats at physiological state. Weight, metabolism of glucose and lipids, and anti-lipid peroxidation of rats were observed.
Results:
6% concentration water extract of Semen Cassiae could significantly reduce the weight and Lee's index, lower the fasting serum levels of triglyceride, insulin and malondialdehyde (MDA).
Conclusions:
Water extract of Semen Cassiae could significantly inhibit the weight gain of high-nutriment-fed rats. The mechanism might be related with its metabolism regulating actions on glucose and lipids.
