Calcific aortic stenosis: same old story?

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Updated: Aug 23, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

S Joanna Cowell1, David E Newby, Nicholas A Boon

  • 1Department of Cardiology, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK. jo.cowell@ed.ac.uk

Age and Ageing
|August 17, 2004
PubMed

Insights

Calcific aortic stenosis, a common heart valve condition, is rising in older adults. This review covers its progression, causes, and current treatments, exploring new therapeutic options.

Area of Science:

  • Cardiology
  • Valvular Heart Disease

Background:

  • Calcific aortic stenosis is the most prevalent adult valvular heart disease globally.
  • Increasing prevalence observed, particularly in aging populations.
  • Aortic valve replacement is a common and successful treatment.

Purpose of the Study:

  • To review the natural history of calcific aortic stenosis.
  • To highlight recent advancements in understanding its pathogenesis.
  • To outline current medical and surgical management strategies and discuss novel therapies.

Main Methods:

  • Literature review of calcific aortic stenosis.
  • Synthesis of current knowledge on pathogenesis.
  • Analysis of existing and emerging treatment modalities.

Main Results:

  • Detailed overview of the disease's progression.
  • Insights into the underlying biological mechanisms.
  • Current treatment landscape including medical, surgical, and interventional approaches.

Conclusions:

  • Calcific aortic stenosis requires ongoing research into its pathogenesis.
  • Management strategies are evolving, with a focus on improved patient outcomes.
  • Novel therapeutic interventions show promise for future treatment.

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