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Updated: Aug 12, 2026

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
Published on: July 17, 2011
The GABA(A) Receptor: Subunit-Dependent Functions and Absence Seizures
C Guin-Ting Wong1, O Carter Snead
1Department of Pharmacology and Department of Pediatrics, University of Toronto, and Faculty of Medicine, Division of Neurology, Brain and Behavior Research Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Abstract:
GABA(A) receptors on thalamic relay and reticular (nRT) neurons play a critical role in thalamocortical mechanisms underlying absence seizures. Studies with absence seizure-prone rats and transgenic mice have taken advantage of differences in the subunit compositions of GABA(A) receptors in the two thalamic cell populations to clarify thalamocortical rhythm generating mechanisms and explain the antiabsence activity of benzodiazepines. The relevance of this work is highlighted by the recent finding of a mutation in the GABA(A) receptor gamma2 subunit in a family with childhood absence seizures.
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