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Updated: Aug 23, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Metabotropic Glutamate Receptors and Epileptogenesis
Robert K. S. Wong1, Shih-Chieh Chuang, Riccardo Bianchi
1Department of Physiology/Pharmacology and Department of Neurology, State University of New York-Health Science Center at Brooklyn, Brooklyn, New York.
Abstract:
Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus. Similarly, the effects of mGluRs on cortical epileptiform activities also are enduring. A transient application of group I mGluR agonists to hippocampal slices produces ictal-like discharges that persist for hours after the removal of the applied agonist. This action of group I mGluRs-transforming "normal" hippocampal slice into an "epileptic-like" one-may represent a form of epileptogenesis. The advent of such a model, in which epileptogenesis can be reliably induced in an in vitro preparation and the process is complete within hours, may facilitate the exploration of cellular mechanisms underlying epileptogenesis.
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