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Related Experiment Videos

Zinc and Epileptogenesis.

F Edward Dudek1

  • 1Department of Anatomy and Neurobiology,Colorado State University, Fort Collins, Colorado.

Epilepsy Currents
|August 17, 2004
PubMed
Summary
This summary is machine-generated.

Zinc

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Area of Science:

  • Neuroscience
  • Neurochemistry

Background:

  • Zinc is concentrated in the hippocampus, particularly in mossy fiber axons.
  • Zinc's role in neurodegeneration and epilepsy has been hypothesized.
  • Previous studies suggested zinc release from reorganized mossy fibers collapses granule-cell inhibition.

Purpose of the Study:

  • To test the hypothesis that synaptically released zinc depresses GABA(A) receptor function.
  • To investigate the role of zinc in hippocampal epilepsy models.

Main Methods:

  • Replication of previous experiments on zinc release in hippocampal slices.
  • Further testing of the zinc-epilepsy hypothesis using in vitro models.

Main Results:

  • Activated mossy fibers in hippocampal slices did not release sufficient zinc.
  • The released zinc was inadequate to depress GABA(A) receptor function at inhibitory synapses.

Conclusions:

  • The hypothesis that zinc release depresses GABA(A) receptor function is complex.
  • In vitro versus in vivo zinc release and extracellular diffusion present challenges to the hypothesis.