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Increased fertilization and pregnancy rate in polypronuclear fertilization cycles in in vitro fertilization-embryo
1Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.
Objective:
To compare fertilization and pregnancy rates between cycles with polypronuclear fertilizations and cycles with normal fertilizations.
Design:
In vitro fertilization-embryo transfer (IVF-ET) cycles in which oocytes were retrieved were divided into two groups according to the nature of fertilization.
Patients:
All patients were participants of our IVF-ET program.
Results:
A significantly higher fertilization rate was found in the polypronuclear fertilization cycles (61% versus 36.6%) and also an improved pregnancy rate (47.5% versus 19.6%) and per embryo transfers (53% versus 28.8%). The vast majority of polypronuclear fertilizations occurred in mature oocytes.
Conclusion:
We believe that the increased receptability of the oocytes improves fertilization and conception rates. The polypronuclear fertilization is an extreme expression of such improved receptibility and should be considered as an encouraging sign for conception.