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Updated: Aug 23, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[Prevalence of pathologic gastroesophageal reflux in regurgitant infants]
Aldo J F Costa1, Giselia A P Silva, Pedro A C Gouveia
1Universidade Federal de Pernambuco (UFPE), Recife, PE. aldojfcosta@terasystem.com.br
Insights
This study found that 11.15% of infants in Recife, Brazil, experienced pathologic gastroesophageal reflux. Regurgitation was more common in the first two trimesters of life, indicating a need for further infant reflux research.
Area of Science:
- Pediatric Gastroenterology
- Infant Health
- Clinical Epidemiology
Context:
- Gastroesophageal reflux is a common concern in infants.
- Rome II criteria are established diagnostic guidelines for functional gastrointestinal disorders.
- Infant regurgitation requires accurate diagnosis to differentiate from pathologic reflux.
Purpose:
- To ascertain the prevalence of pathologic gastroesophageal reflux in infants presenting with regurgitation.
- To apply standardized diagnostic criteria (Rome II) for accurate assessment.
- To investigate potential age-related patterns in infant reflux.
Summary:
- A cross-sectional study involving 798 infants under one year of age with a history of regurgitation was conducted.
- The prevalence of pathologic gastroesophageal reflux was determined to be 11.15% (89/798).
- Higher prevalence rates were observed in the first two trimesters of infancy.
Impact:
- Provides crucial epidemiological data on infant reflux in Brazil.
- Highlights the importance of early diagnosis and management of gastroesophageal reflux disease in infants.
- Contributes to the global understanding of infant regurgitation and its underlying causes.
Objective:
To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria.
Method:
The study design was transversal. The patients were all children of less than 1 year of age with a history of episodes of regurgitation for at least 3 weeks. The study group was comprised of 798 children who attended the program between January and August of 2002. The diagnostic criteria were based on Rome II criteria.
Results:
The prevalence of pathologic gastroesophageal reflux was 11.15% (89/798) (95% CI 9.10-13.48). It was higher during the first two trimesters of life, 14.62% (31/212) (95% CI 10.33-19.86) in the first trimester, and 13.76% (38/276) (95% CI 10.07-18.21) in the second trimester.
Conclusion:
The prevalence of pathologic gastroesophageal reflux within the group of children examined concurred with previously published studies, with predominance, therefore, of regurgitant infants.
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