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Expression of TREM-1 mRNA in acute pancreatitis

Da-Yu Wang1, Ren-Yi Qin, Zheng-Ren Liu

  • 1Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.

World Journal of Gastroenterology
|August 17, 2004
PubMed
Abstract

Insights

Triggering receptor expressed on myeloid cells (TREM-1) mRNA levels are elevated in acute pancreatitis (AP) and correlate with disease severity. TREM-1 expression changes significantly during AP progression and treatment, suggesting its role in the condition.

Area of Science:

  • Immunology
  • Gastroenterology
  • Molecular Biology

Background:

  • Acute pancreatitis (AP) is a serious inflammatory condition of the pancreas.
  • The role of immune receptors in AP pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the messenger RNA (mRNA) expression levels of triggering receptor expressed on myeloid cells (TREM-1) in patients with acute pancreatitis.
  • To determine the correlation between TREM-1 mRNA expression and the severity and clinical stages of AP.

Main Methods:

  • Reverse transcription polymerase chain reaction (RT-PCR) was employed to quantify TREM-1 mRNA expression.
  • Expression levels were analyzed in three groups: mild AP (MAP), severe AP (SAP), and healthy controls.
  • TREM-1 mRNA was also assessed in AP patients at different stages: before treatment, after successful therapy, and after clinical cure.

Main Results:

  • TREM-1 mRNA expression was significantly higher in both MAP and SAP patients compared to healthy controls (P<0.05).
  • Expression levels showed a significant difference among MAP, SAP, and control groups.
  • A significant decrease in TREM-1 mRNA expression was observed as AP progressed from before treatment to successful therapy and clinical cure (P<0.05).

Conclusions:

  • TREM-1 mRNA expression is significantly upregulated in acute pancreatitis.
  • TREM-1 mRNA levels correlate with the severity and clinical stages of AP.
  • These findings suggest that TREM-1 plays a crucial role in the development and progression of acute pancreatitis.

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