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Related Experiment Videos

A patient with repeated syncopal attacks after using isosorbide dinitrate.

S Haraoka, D Saito, M Miyasaka

    Acta Medica Okayama
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    This case report details an 81-year-old female experiencing recurrent collapse after sublingual isosorbide dinitrate. Reduced venous return, not vagal reflex, was the likely cause of these syncopal episodes.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Isosorbide dinitrate is a common treatment for angina.
    • Adverse reactions can occur with vasodilator medications.

    Observation:

    • An 81-year-old female experienced syncope following sublingual isosorbide dinitrate administration for chest pain.
    • Episodes involved profound hypotension and ST-segment elevation, resolving with norepinephrine.

    Findings:

    • Repeated syncopal episodes were induced by isosorbide dinitrate.
    • The mechanism was attributed to decreased venous return, excluding vagal reflex augmentation.

    Implications:

    • Clinicians should be aware of potential severe hypotensive reactions to sublingual isosorbide dinitrate.
    • Careful monitoring is advised in elderly patients or those with risk factors for reduced venous return.

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