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Updated: Aug 23, 2026

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique
Published on: June 12, 2015
Computational-fluid-dynamics (CFD) analysis of mixing and gas-liquid mass transfer in shake flasks
Hu Zhang1, Wellae Williams-Dalson, Eli Keshavarz-Moore
1Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
Abstract:
CFD (computational fluid dynamics) techniques were used to predict mixing and gas-liquid mass transfer in a 250 ml shake flask operating over a range of shaking frequencies between 100 and 300 rev./min, shaking diameters between 20 and 60 mm, and fill volumes between 25 and 100 ml. Interfacial area, a, volumetric mass-transfer coeffcient, kLa, and the power input per unit volume, epsilonv, of the liquid were predicted to be 300
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