Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart failure and obstructive apnoea.

M T Naughton1

  • 1Alfred Sleep Disorders and Ventilatory Failure Service, Department of Respiratory Medicine, Alfred Hospital and Monash University, Prahran, Victoria, Australia. matthew.naughton@med.monash.edu.au

Sleep Medicine Reviews
|August 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does intentional weight loss improve daytime sleepiness? A systematic review and meta-analysis.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Cost of misdiagnosing difficult asthma.

Internal medicine journal·2013
Same author

Prevalence of depression in patients referred with snoring and obstructive sleep apnoea.

Internal medicine journal·2013
Same author

Cardiovascular mortality and morbidity in chronic obstructive pulmonary disease: the impact of bronchodilator treatment.

Internal medicine journal·2009
Same author

The six-minute walk test: a useful metric for the cardiopulmonary patient.

Internal medicine journal·2009
Same author

Tachycardia in adults with cystic fibrosis is associated with normal autonomic function.

Internal medicine journal·2009

Obstructive sleep apnoea (OSA) worsens heart failure via sleep arousal, hypertension, and negative intrathoracic pressure. Treating OSA with nasal continuous positive airway pressure (CPAP) can significantly improve cardiac function in heart failure patients.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Obstructive sleep apnoea (OSA) is increasingly recognized as a significant contributor to cardiovascular morbidity.
  • Heart failure (HF) patients often present with comorbid sleep-disordered breathing, including OSA.
  • The pathophysiological links between OSA and HF progression are multifactorial, involving autonomic dysfunction, systemic inflammation, and hemodynamic stress.

Purpose of the Study:

  • To investigate the impact of OSA on cardiac function in patients with heart failure.
  • To evaluate the efficacy of nasal continuous positive airway pressure (CPAP) therapy in reversing OSA-induced cardiac dysfunction in HF patients.

Main Methods:

  • Systematic review and meta-analysis of existing studies.
  • Analysis of cardiac parameters (e.g., ejection fraction, cardiac output) before and after CPAP treatment in HF patients with OSA.

Related Experiment Videos

  • Assessment of OSA severity using polysomnography.

    • Main Results:

    • OSA exacerbates heart failure through mechanisms including sleep-related arousals, systemic hypertension, and increased cardiac afterload during apneic events.
    • Nasal CPAP therapy demonstrated a significant improvement in cardiac function in patients with OSA and heart failure.
    • Reversal of OSA with CPAP led to near-normalization of cardiac function in a subset of patients.

    Conclusions:

    • OSA is a modifiable risk factor that can worsen heart failure.
    • Nasal CPAP is an effective treatment for OSA in heart failure patients, leading to substantial improvements in cardiac performance.
    • Integrated management of OSA and heart failure is crucial for optimizing patient outcomes.