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Related Experiment Videos

Photosensitization caused by ibuprofen.

T Bergner1, B Przybilla

  • 1Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Federal Republic of Germany.

Journal of the American Academy of Dermatology
|January 1, 1992
PubMed
Summary
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Ibuprofen, a common pain reliever, may cause photosensitivity reactions. In vitro studies show ibuprofen can damage red blood cells when exposed to UVA light, suggesting a potential mechanism for this drug-induced photosensitivity.

Area of Science:

  • Dermatology
  • Pharmacology
  • Photobiology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like benoxaprofen, carprofen, and piroxicam are known photosensitizers.
  • Photosensitivity reactions induced by ibuprofen have not been previously documented.

Observation:

  • A patient treated with oral ibuprofen developed a photosensitivity reaction.
  • The patient exhibited a reduced minimal erythema dose for UVA radiation after ibuprofen administration.
  • Photopatch testing with ibuprofen yielded negative results.

Findings:

  • In vitro experiments demonstrated that UVA irradiation of human erythrocytes in the presence of ibuprofen induced dose-dependent phototoxic hemolysis.
  • This suggests a direct phototoxic mechanism of ibuprofen on red blood cells.

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Implications:

  • Ibuprofen may be a potential photosensitizer, contrary to previous understanding.
  • The findings suggest a need for increased awareness of photosensitivity in patients taking ibuprofen.
  • Further research is warranted to elucidate the clinical significance and prevalence of ibuprofen-induced photosensitivity.