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DisProt: a database of protein disorder.

Slobodan Vucetic1, Zoran Obradovic, Vladimir Vacic

  • 1Center for Information Science and Technology, Temple University Philadelphia, PA 19122, USA.

Bioinformatics (Oxford, England)
|August 18, 2004
PubMed
Summary

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The DisProt database offers comprehensive information on intrinsically disordered proteins, crucial for understanding protein structure and function. It serves as a central resource for disordered protein data.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • The Database of Protein Disorder (DisProt) is a curated resource.
  • It focuses on proteins lacking fixed three-dimensional structures.
  • Intrinsic disorder is recognized as a significant protein structural class.

Purpose of the Study:

  • To establish DisProt as a central repository for information on intrinsically disordered proteins.
  • To provide detailed data on protein disorder and its functional implications.

Main Methods:

  • Curating data on disordered proteins.
  • Compiling information on protein names, aliases, accession codes, and amino acid sequences.
  • Documenting disordered regions, characterization methods, and biological functions.

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Main Results:

  • DisProt entries include location of disordered regions and methods for characterization.
  • Biological functions associated with disordered regions are detailed.
  • Links to PubMed and major protein databases are provided for further reference.

Conclusions:

  • DisProt is a valuable resource for researchers studying intrinsically disordered proteins.
  • The database facilitates understanding the structure-function relationships of these proteins.