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Recombinant activated factor VII decreases bleeding without increasing arterial thrombosis in rabbits

Maurizio Fattorutto1, Sandrine Tourreau-Pham, Elisabeth Mazoyer

  • 1Département d'Anesthésie-Réanimation, Hôpital Avicenne, 125 route de Stalingrad, 93009 Bobigny cedex, France.

Summary

Recombinant activated factor VII (rFVIIa) reduced bleeding time and microvascular blood loss in a rabbit model. However, rFVIIa did not significantly impact arterial thrombosis, suggesting targeted hemostatic benefits without pro-thrombotic effects.

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