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Microfluidics in Assessing Platelet Function
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Prolonged profound abciximab associated immune thrombocytopenia complicated by transient multispecific platelet

J A G Lown1, A S Hughes, P Cannell

  • 1Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia. john.lown@health.wa.gov.au

Heart (British Cardiac Society)
|August 18, 2004
PubMed

Patients receiving abciximab occasionally develop transient severe thrombocytopenia within a few hours of receiving the drug. Thrombocytopenia has been reported to resolve within 10 days of abciximab administration, but in this case profound thrombocytopenia lasted 21 days before a slow spontaneous recovery. Management was complicated by the presence of HLA antibodies and the transient production of antibodies directed at major platelet glycoproteins IIb/IIIa, Ib/IX, and Ia/IIa. The patient remained refractory to platelet transfusion and two courses of intravenous gammaglobulin for the duration of her admission.

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