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Updated: Aug 23, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
Published on: July 12, 2018
[Excess mortality by diarrhea simultaneous to a cholera epidemic in Northeastern Brazil]
Moacir Gerolomo1, Maria Lúcia Fernandes Penna
1Fundação Nacional de Saúde, Ministério da Saúde, Curitiba, PR, Brazil. moacir.gerolomo@saude.gov.br
Objective:
To evaluate excess mortality due to infectious diarrhea without etiological diagnosis, occurring simultaneously to Vibrio cholerae circulation.
Methods:
Statistical modeling was applied to a time series of deaths ascribed to "poorly defined intestinal infections" (International Classification of Diseases -- ICD-9) and "presumably infectious diarrhea and gastroenteritis" (ICD-10), between 1980 and 1998 in the Northeast region of Brazil. The prediction of expected values was obtained after a discontinuity point. Excess mortality was calculated as the difference between observed figures and those estimated by the model.
Results:
Between 1992 and 1994, only 19.3% of deaths by cholera were actually notified. In 1993, the year in which the epidemic reached its peak in the area, our modeling estimated underregistration at 82.2%.
Conclusions:
Results indicate substantial underregistration of cholera mortality during the epidemic in Northeastern Brazil.
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